Airway Mucosal Immune-suppression in Neonates of Mothers Receiving A(H1N1)pnd09 Vaccination During P
Airway Mucosal Immune-suppression in Neonates of Mothers Receiving A(H1N1)pnd09 Vaccination During Pregnancy
This is the first study to assess airway immunology in neonates of mothers vaccinated during pregnancy, thereby presenting an unprecedented opportunity to explore the influence of antenatal vaccination on neonatal mucosal cytokine and chemokine immunology. Our findings suggest that H1N1pnd09 vaccination during pregnancy affects the mucosal immune competence of the unborn child and that this effect is dependent on the lag-time between vaccination and birth.
We observe a 1.6-fold increase in TGF-β1, along with decreased levels of the remaining immune mediators in upper airway of neonates from vaccinated mothers demonstrating that the fetal immune response is indeed hampered by the maternal immune activation propagated by the vaccination protocol.
This is a notable finding, underscoring the necessity for research into vaccination programs in pregnant women and their influence on the neonatal immunity, not only focusing on neonatal immunity against the specific disease and the vaccine antigens, but the general immune status of the newborn child.
Conclusion
This is the first study to assess airway immunology in neonates of mothers vaccinated during pregnancy, thereby presenting an unprecedented opportunity to explore the influence of antenatal vaccination on neonatal mucosal cytokine and chemokine immunology. Our findings suggest that H1N1pnd09 vaccination during pregnancy affects the mucosal immune competence of the unborn child and that this effect is dependent on the lag-time between vaccination and birth.
We observe a 1.6-fold increase in TGF-β1, along with decreased levels of the remaining immune mediators in upper airway of neonates from vaccinated mothers demonstrating that the fetal immune response is indeed hampered by the maternal immune activation propagated by the vaccination protocol.
This is a notable finding, underscoring the necessity for research into vaccination programs in pregnant women and their influence on the neonatal immunity, not only focusing on neonatal immunity against the specific disease and the vaccine antigens, but the general immune status of the newborn child.