Amniotic Fluid Embolism Incidence, Risk Factors and Outcomes
Amniotic Fluid Embolism Incidence, Risk Factors and Outcomes
This analysis has highlighted the benefits of detailed comparison of AFE incidence and ascertainment methods from different population-based studies and has identified a number of difficulties with making direct international comparisons. The study methodology impacts on estimates of disease incidence and case fatality, and may also account for inconsistencies in reported risk factors. There is a need for consistent study methodologies, including agreed case definition and case validation criteria. The use of such unified methodologies will allow for valid international comparisons of incidence in the future, and may permit pooling of international data to provide more reliable information on associated factors, management and outcomes, thus allowing for development of preventive and treatment strategies to improve outcomes of this rare but serious condition.
Conclusions
This analysis has highlighted the benefits of detailed comparison of AFE incidence and ascertainment methods from different population-based studies and has identified a number of difficulties with making direct international comparisons. The study methodology impacts on estimates of disease incidence and case fatality, and may also account for inconsistencies in reported risk factors. There is a need for consistent study methodologies, including agreed case definition and case validation criteria. The use of such unified methodologies will allow for valid international comparisons of incidence in the future, and may permit pooling of international data to provide more reliable information on associated factors, management and outcomes, thus allowing for development of preventive and treatment strategies to improve outcomes of this rare but serious condition.