Serum Peptide Biomarkers of Biliary Tract Cancer
Serum Peptide Biomarkers of Biliary Tract Cancer
In conclusion we have defined a serum peptide signature and model than can accurately discriminate patients with BTC from healthy volunteers and which was validated on an independent sample set. A model using an overlapping set of peptides was also derived that could differentiate malignant from benign disease, albeit with a lower, but respectable, accuracy. Further independent validation of this model is now required using greater numbers of samples from patients with PSC and other benign conditions to test its robustness for the differential diagnosis of BTC.
Conclusions
In conclusion we have defined a serum peptide signature and model than can accurately discriminate patients with BTC from healthy volunteers and which was validated on an independent sample set. A model using an overlapping set of peptides was also derived that could differentiate malignant from benign disease, albeit with a lower, but respectable, accuracy. Further independent validation of this model is now required using greater numbers of samples from patients with PSC and other benign conditions to test its robustness for the differential diagnosis of BTC.