Burdens of SREs Associated With Bone Metastases
Burdens of SREs Associated With Bone Metastases
Data relating to the humanistic impact of SREs (i.e., utilities and disutilities) were scarce. Despite the search strategy having been applied broadly to maximize the potential for identifying SRE-related utility values, few primary studies (n = 3; Table 6) were found to have reported original utility values for patients with bone metastases and SREs. Within the three studies identified, ten utility values for SRE health states were reported. Two of the studies reported values assessed empirically via the time trade-off approach or the administration of the EQ-5D, and one study reported values based on the author's opinion. Comparison on the basis of utility values indicates that, among SREs with more than one value reported, spinal cord compression was associated with the worst quality of life, followed by bone surgery. Further comparison of SRE-related utility values was hindered by very limited data.
Humanistic Effect of SREs
Data relating to the humanistic impact of SREs (i.e., utilities and disutilities) were scarce. Despite the search strategy having been applied broadly to maximize the potential for identifying SRE-related utility values, few primary studies (n = 3; Table 6) were found to have reported original utility values for patients with bone metastases and SREs. Within the three studies identified, ten utility values for SRE health states were reported. Two of the studies reported values assessed empirically via the time trade-off approach or the administration of the EQ-5D, and one study reported values based on the author's opinion. Comparison on the basis of utility values indicates that, among SREs with more than one value reported, spinal cord compression was associated with the worst quality of life, followed by bone surgery. Further comparison of SRE-related utility values was hindered by very limited data.