A Novel Means of Detecting Parkinson Disease
A Novel Means of Detecting Parkinson Disease
Berg D, Seppi K, Behnke S, et al
Arch Neurol. 2011;68:932-937
If patients with subclinical pathologic features of Parkinson disease (PD) could be identified before they developed symptoms, it could open a window for early neuroprotective intervention.
The substantia nigra (SN) of the midbrain is involved early in the pathogenesis and course of PD, and transcranial sonography has shown that 90% of patients with PD (but only about 10% of elderly control patients) have SN hyperechogenicity. However, it was not previously determined whether SN hyperechogenicity could predict subsequent development of PD in still-healthy persons.
Enlarged Substantia Nigra Hyperechogenicity and Risk for Parkinson Disease: A 37-Month 3-Center Study of 1847 Older Persons
Berg D, Seppi K, Behnke S, et al
Arch Neurol. 2011;68:932-937
Study Background
If patients with subclinical pathologic features of Parkinson disease (PD) could be identified before they developed symptoms, it could open a window for early neuroprotective intervention.
The substantia nigra (SN) of the midbrain is involved early in the pathogenesis and course of PD, and transcranial sonography has shown that 90% of patients with PD (but only about 10% of elderly control patients) have SN hyperechogenicity. However, it was not previously determined whether SN hyperechogenicity could predict subsequent development of PD in still-healthy persons.