Warnings

• Due to possible fatal side effects, do not take Zoloft along with certain drugs, including: pimozide, isocarboxazid or other MAO inhibitors, phenelzine, selegiline, tranylsypromine or rasagiline. Also inform your doctor if you have seizures or epilepsy, kidney or liver disease, substance abuse issues, suicidal tendencies or bipolar disorder.
  
  

Allergic Reactions

• Get emergency help right away for any of the following allergic reactions: breathing difficulties; hives or skin rash; or swelling of your face, tongue, throat or lips.
  
  

Red-Flag Symptoms

• Call your doctor if any of the following symptoms develop or worsen, for a possible medication adjustment: changes in mood or behavior, panic attacks, anxiety, sleeping troubles, irritability, agitation, hostility, aggression, restlessness, impulsiveness, mental or physical hyperactivity, suicidal thoughts or increased depression.
  
  

Minor Side Effects

• Some minor Zoloft side effects include: dry mouth, sleep disturbances, appetite or weight changes, lack of interest in sex or impotence, stomach pain or upset, constipation or light nausea, and feeling tired, dizzy or drowsy.
  
  

Major Side Effects

• Contact your doctor for any of the following major side effects: high fever, sweating, uneven or fast heartbeat, tremors, stiff muscles, overactive reflexes, nausea, vomiting, loss of appetite, diarrhea, an unsteady feeling, loss of coordination, headache, confusion, fainting, hallucinations, shallow breathing, trouble with memory or concentrating, seizures or weakness.
  
  

Interactions

• Taking Zoloft and NSAIDS, such as ibuprofen, may cause you to bruise or bleed more easily. Also use caution when taking Zoloft with any of the following drugs: digitoxin, tramadol, lithium, warafin or other blood thinners, phenytoin, valproate, other antidepressants aside from Zoloft, hearth rhythm medications, almotriptan, frovatriptan, naratriptan, sumatripton, zolmitriptan or rizatriptan.