Fatigue that Never Quits Epstein-Barr virus, Chronic Fatigue Syndrome and Chronic Lyme Disease Conne
Epstein-Barr (EBV) is also known as HHV-4 and is a common virus that is contracted by nearly everyone at some point during life. It is possible for EBV can remain dormant in the body throughout the entirety of an individual's life span. In most cases, EBV is passed through saliva and typically does not present until 4-6 weeks from initial contact and is most often spread during this period. When infection last longer than it should one must consider Chronic Lyme Disease complex.
Children and Autoimmunity, Autism-like Symptoms, and Chronic Fatigue Syndrome
Children typically show no symptoms with EBV, however, adolescents who are infected will suffer with mononucleosis anywhere from 35 to 50 percent of the time. Fever, sore throat, swollen lymph glands, elevated white blood cells counts, and even swollen liver and spleen round out presenting symptoms of infectious mononucleosis €" a disease directly affected by EBV. If symptoms of mononucleosis persist beyond six months, Lyme disease testing or a Chronic Fatigue Syndrome (CFS) evaluation should be considered by care provider.
Should Lyme disease already be present, the bacteria/infections will tend to grow at a far more accelerated rate than usual - often leading to symptoms resembling those of Autism. In fact there are some cases, albeit rare, that have seen impact on the heart and central nervous system. Proper Lyme disease testing including CD57, and co-infection panels of viral, parasite and bacterial should be conducted.
Co-infection of Chronic Lyme disease Co-infection Epstein Barr - Linked to Autoimmune Diseases and MS
A pattern of association has been drawn between Epstein-Barr and Multiple Sclerosis as well as other autoimmune diseases. With regards to Lyme disease co-infection EBV, a leading world researcher pointed out that among MS related brain lesions, abnormal accumulations of EBV infected B lymphocytes were found consistently. This observation shares similarities with studies focused on the pathological tissues of those suffering with other autoimmune diseases.
Lyme disease (and other tick-borne zoonotic illness) has been clinically shown to suggest viruses can be activated in its presence. Simply put, a human carrier of herpetic virus when combined with another infection can activate Epstein Barr, thereby accelerating patient fatigue, in addition to many other potential symptoms associated with other autoimmune diseases and neurological symptoms.
Epstein Barr and Autoimmune Disease Link to Viruses
Immunologists have long suspected viruses as being the silent triggers of autoimmune diseases with their unrivaled ability to interfere with the immune systems of their hosts. EBV, which infects up to 95 percent of the human global population, has been repeatedly associated with MS through epidemiological and serological studies. However, direct proof of its involvement had been much harder to come by.
The virus can hide in the immune system's B lymphocytes and remain relatively dormant throughout the life of the host. However, should the immune system fail to properly control it, EBV can reactivate and begin to cause tumors in the process. Chronic Lyme disease can bring about re-activation of Epstein Barr among other viruses that have carcinogenic potential.
In 2007 it was shown that EBV is present in the brain lesions of MS patients after being transported into the central nervous system by B lymphocytes. It was also made evident that these infected B cells, when they do present in the brain, become the target of an immune attack. This often will cause a situation leading to chronic inflammation and eventually tissue destruction. Seemingly, EBV and its €unwilling smuggler€ B cells are the main cause of brain damage in MS patients. This abnormal accumulation of EBV infected B cells is found among pathological tissues in other autoimmune diseases as well.
Progression of Autoimmune Diseases and MS
Infectious mononucleosis-causing pathogen, Epstein-Barr virus (EBV), plays a significant role in the facilitation of neurodegeneration among MS sufferers. At Envita, we work to speed healing time and boost the immune systems in those with EBV. In fact, EBV could be the environmental factor necessary to initiate the disease in adults. Moreover, it could likely be the increased immunological response to EBV infection in MS that actually leads to the disease's characteristic immune dysregulation. Lyme disease testing and co-infections such as Epstein Barr need to be tested and treated properly.
However, as MS patients do not usually have increased immune responses to other common viruses, the higher rate of EBV seroprevalence (coupled with the higher anti-EBV antibody titre) cannot be the result of some hyper-immune state in MS patients. It seems instead that the increased risk for MS, particularly in those of higher age, decidedly points to an irrefutable link between MS and EBV. It may even be that EBV is completely requisite for MS to develop in adults.
Journal of Neurology, Neurosurgery, and Psychiatry
Professor of medicine and multiple sclerosis expert Robert Zivadinov shares, "A growing body of experimental evidence indicates that past infection with EBV may play a role in MS - but the relationship of EBV and the brain damage that can be seen on MRI scans had not been explored."
In one study, one hundred thirty-five patients diagnosed with MS participated at University of Trieste's Multiple Sclerosis Center. Researchers, led by Zivadinov, found definitively that higher levels of anti-EVB antibody measured at the study's origin appeared to have a direct correlation to a decrease in both gray matter - and total brain volume - over the course of the three-year follow-up.
Virology of Epstein Barr
EBV is a DNA virus that multiplies within the nucleus of its host cells. It infects both B-cells and epithelial cells - establishing latent infections in the Bs and actually multiplying in the epithelials. Infected persons are then likely to produce virions (inert carriers of the EBV genome), carry and produce EBV-specific antibody, and harbor latently infected memory B-cells. Ultimately, what we see from EBV is an extremely sophisticated technique for the virus to avoid and escape the host's immune system defenses.
Bringing about Cancer
Recent studies have shown that among immunosuppressed patients, EBV is closely linked to B-cell malignancies such as Hodgkin's lymphoma (HL) and lymphoproliferative disease. EBV and some T-cell lymphomas are also likely related, while other epithelial tumors such as gastric cancers can similarly develop. The presence of multiple extrachromosomal copies of the viral genome in tumor cells and the expression of part of the EBV genome, characterize these tumors.
Envita Medical Centers
Envita is a premier integrative medical center that provides cancer and chronic disease treatment options from across the globe. Envita's LLMD (Lyme Literate Doctors) have developed revolutionary protocols to help patients improve their immune systems and their overall quality of life. Envita excels by treating disease causes rather than by addressing symptoms alone.
For more information or to schedule a consultation, please contact Envita Medical Centers today.
References:
World health Organization viral cancers Epstein Barr
Genes and Immunity (2012)
National Center for Infectious Diseases, cdc.gov
Linking Epstein-Barr Virus To Multiple Sclerosis Science Daily (Sep. 14, 2009)
Children and Autoimmunity, Autism-like Symptoms, and Chronic Fatigue Syndrome
Children typically show no symptoms with EBV, however, adolescents who are infected will suffer with mononucleosis anywhere from 35 to 50 percent of the time. Fever, sore throat, swollen lymph glands, elevated white blood cells counts, and even swollen liver and spleen round out presenting symptoms of infectious mononucleosis €" a disease directly affected by EBV. If symptoms of mononucleosis persist beyond six months, Lyme disease testing or a Chronic Fatigue Syndrome (CFS) evaluation should be considered by care provider.
Should Lyme disease already be present, the bacteria/infections will tend to grow at a far more accelerated rate than usual - often leading to symptoms resembling those of Autism. In fact there are some cases, albeit rare, that have seen impact on the heart and central nervous system. Proper Lyme disease testing including CD57, and co-infection panels of viral, parasite and bacterial should be conducted.
Co-infection of Chronic Lyme disease Co-infection Epstein Barr - Linked to Autoimmune Diseases and MS
A pattern of association has been drawn between Epstein-Barr and Multiple Sclerosis as well as other autoimmune diseases. With regards to Lyme disease co-infection EBV, a leading world researcher pointed out that among MS related brain lesions, abnormal accumulations of EBV infected B lymphocytes were found consistently. This observation shares similarities with studies focused on the pathological tissues of those suffering with other autoimmune diseases.
Lyme disease (and other tick-borne zoonotic illness) has been clinically shown to suggest viruses can be activated in its presence. Simply put, a human carrier of herpetic virus when combined with another infection can activate Epstein Barr, thereby accelerating patient fatigue, in addition to many other potential symptoms associated with other autoimmune diseases and neurological symptoms.
Epstein Barr and Autoimmune Disease Link to Viruses
Immunologists have long suspected viruses as being the silent triggers of autoimmune diseases with their unrivaled ability to interfere with the immune systems of their hosts. EBV, which infects up to 95 percent of the human global population, has been repeatedly associated with MS through epidemiological and serological studies. However, direct proof of its involvement had been much harder to come by.
The virus can hide in the immune system's B lymphocytes and remain relatively dormant throughout the life of the host. However, should the immune system fail to properly control it, EBV can reactivate and begin to cause tumors in the process. Chronic Lyme disease can bring about re-activation of Epstein Barr among other viruses that have carcinogenic potential.
In 2007 it was shown that EBV is present in the brain lesions of MS patients after being transported into the central nervous system by B lymphocytes. It was also made evident that these infected B cells, when they do present in the brain, become the target of an immune attack. This often will cause a situation leading to chronic inflammation and eventually tissue destruction. Seemingly, EBV and its €unwilling smuggler€ B cells are the main cause of brain damage in MS patients. This abnormal accumulation of EBV infected B cells is found among pathological tissues in other autoimmune diseases as well.
Progression of Autoimmune Diseases and MS
Infectious mononucleosis-causing pathogen, Epstein-Barr virus (EBV), plays a significant role in the facilitation of neurodegeneration among MS sufferers. At Envita, we work to speed healing time and boost the immune systems in those with EBV. In fact, EBV could be the environmental factor necessary to initiate the disease in adults. Moreover, it could likely be the increased immunological response to EBV infection in MS that actually leads to the disease's characteristic immune dysregulation. Lyme disease testing and co-infections such as Epstein Barr need to be tested and treated properly.
However, as MS patients do not usually have increased immune responses to other common viruses, the higher rate of EBV seroprevalence (coupled with the higher anti-EBV antibody titre) cannot be the result of some hyper-immune state in MS patients. It seems instead that the increased risk for MS, particularly in those of higher age, decidedly points to an irrefutable link between MS and EBV. It may even be that EBV is completely requisite for MS to develop in adults.
Journal of Neurology, Neurosurgery, and Psychiatry
Professor of medicine and multiple sclerosis expert Robert Zivadinov shares, "A growing body of experimental evidence indicates that past infection with EBV may play a role in MS - but the relationship of EBV and the brain damage that can be seen on MRI scans had not been explored."
In one study, one hundred thirty-five patients diagnosed with MS participated at University of Trieste's Multiple Sclerosis Center. Researchers, led by Zivadinov, found definitively that higher levels of anti-EVB antibody measured at the study's origin appeared to have a direct correlation to a decrease in both gray matter - and total brain volume - over the course of the three-year follow-up.
Virology of Epstein Barr
EBV is a DNA virus that multiplies within the nucleus of its host cells. It infects both B-cells and epithelial cells - establishing latent infections in the Bs and actually multiplying in the epithelials. Infected persons are then likely to produce virions (inert carriers of the EBV genome), carry and produce EBV-specific antibody, and harbor latently infected memory B-cells. Ultimately, what we see from EBV is an extremely sophisticated technique for the virus to avoid and escape the host's immune system defenses.
Bringing about Cancer
Recent studies have shown that among immunosuppressed patients, EBV is closely linked to B-cell malignancies such as Hodgkin's lymphoma (HL) and lymphoproliferative disease. EBV and some T-cell lymphomas are also likely related, while other epithelial tumors such as gastric cancers can similarly develop. The presence of multiple extrachromosomal copies of the viral genome in tumor cells and the expression of part of the EBV genome, characterize these tumors.
Envita Medical Centers
Envita is a premier integrative medical center that provides cancer and chronic disease treatment options from across the globe. Envita's LLMD (Lyme Literate Doctors) have developed revolutionary protocols to help patients improve their immune systems and their overall quality of life. Envita excels by treating disease causes rather than by addressing symptoms alone.
For more information or to schedule a consultation, please contact Envita Medical Centers today.
References:
World health Organization viral cancers Epstein Barr
Genes and Immunity (2012)
National Center for Infectious Diseases, cdc.gov
Linking Epstein-Barr Virus To Multiple Sclerosis Science Daily (Sep. 14, 2009)