Updated October 21, 2014.

Definition:

A street slang term for depressants.

The term is one of more than 2,300 street terms that refer to specific drug types or drug activity compiled by the White House Office of National Drug Control Policy.
Slang terms can vary from one region of the country to another and even from one neighborhood to another.
Also Known As: Sedatives, downers

Examples: When they heard her mention 'Mighty Joe Young' on the phone, they did not realize that she was referring to depressants.