BETTER SEXUAL PERFORMANCE WITH AN ANTIBIOTIC. FERTILITY RISK IF YOU USE YOUR PHONE TOO
By the end of the year are expected results of the Phase IIb clinical trial of the acidity clavulanic acid (inhibitor of the enzyme beta lactamasi, known antibiotic), confirmation (or refutation) of its possible use as a therapy to increase sexual performance in the male. The positive results emerged from the previous Phase IIa clinical trial were in fact open to a possible treatment for all men with erectile dysfunction (30%) which, due to contraindications related to cardiovascular risk such as heart attack, cannot assume the inhibitors of phosphodiesterase 5 (PDE-5), the standard oral therapy available today.
"That's because, unlike drugs that intervene only available on erectile function, clavulanic acid acts on the central nervous system, acting on the action of serotonin and dopamine, molecules that play a key role in all 3 phases of sexual function, arousal, erection and release. This is the first solution capable of acting in this manner - explains Prof.
Furio Pirozzi Farina, President of the Italian Society of Andrology - The mechanism of action of clavulanic acid, in addition to showing positive effects the male with ED of psychogenic origin, opens up new hopes for the treatment of disorders related to arousal problems, such as premature ejaculation, and also in the treatment of female sexual dysfunction. "After the publication [i] in 2009 study preclinical rat produced by the University of Utrecht (Netherlands) from which emerged an increase in sexual activity following the administration of the drug, the trial continued with a human clinical trial Phase IIa double-blind, randomized, placebo-controlled trial that evaluated the safety and preliminary efficacy in 39 males aged between 18 and 65 years with ED.
The improvement of erectile function score was measured by the International Index of Erectile Function (IIEF) at a time 8 weeks, also highlighting improved quality of life. Clavulanic acid has been proven safe and well tolerated without significant adverse events. The Phase IIb study (in progress) is double-blind, randomized, placebo-controlled, of 225 men with ED, aged between 18 and 65. The assessment shall include as endpoints, the Sexual Encounter Profile (SEP), assessment of sexual function questionnaire, the IIEF and the assessment of quality of life.
"Dysfunction dysfunction and sexual performance are the issues on which, thanks to a series of initiatives to raise awareness at national and local, has torn the veil of embarrassment - says Pirozzi Farina - Little is known, for example, infertility and factors risk, and there are many misconceptions and falsehoods that revolve around the male sexual health. Much has been achieved in recent years, but the same must be done to ensure that culture andrological and take care of their sexuality take root among the Italian men.
"For several years debating the risks to health from exposure to electromagnetic waves, especially those emitted by mobile phones, more and more accessible to adults and adolescents, especially in Western countries. One of the themes of particular interest is related to the influence on sperm quality and thus the impairment of reproductive capacity. A study recently conducted by experts from the University of Catania and published in the journal International Journal of Andrology analyzes several research done on animals and humans to observe the effects on reproductive capacity which can be caused by exposure to electromagnetic radiation of mobile phones.
"The scientific community continues to reflect the adverse effects of electromagnetic waves, especially in light of the increasingly widespread use of mobile phones in Western populations and the simultaneous reduction fertility - says Pirozzi Farina - In the peninsula, from the 70s to today, men have seen a decrease in the number of spermatozoa in a milliliter of semen has gone from 71 million to 60 million. And if thirty years ago a sperm of two was mobile, now it is only 30%. So there is a fertility problem, but it is important to clarify what can be considered truly dangerous items and substances for general health and sexual, so as not to create unnecessary alarm.
"The damage caused by radiation from mobile phones through hyperthermia and oxidative stress, are located mainly in the Leydig cells, and sperm in the tubules seminifere. The exposure reduces testosterone biosynthesis in particular, impairs spermatogenesis and sperm DNA damage. "The first recommendation to do is to avoid holding the phone in the pocket of his pants - adds Pirozzi Farina - The same precaution should be taken with other equipment, for example, when using the laptop resting on my legs. Equally important is to contain the 'use. Some studies in fact show that the degree of damage of the sperm is directly linked to the time of exposure to electromagnetic radiation. Both of these bad habits can lead to hyperthermia and oxidative stress.
"The consequences are found in both the mobility in the morphology of spermatozoa. The increase of oxidative stress also affects the lipid membrane and the DNA of sperm. "These are changes that appear to be directly related to prolonged use of the phone. To date, however, no studies of well depth decree the negative interference on the reproductive function.
There is, however, evidence of other risk factors for reproduction, such as environmental pollution. Lead, carbon monoxide and fine dust accumulate in the testicles with effects on sperm. The Studies prove who is very exposed, such as policemen or toll collectors "- concludes Pirozzi Farina. Several studies also show that in men living in large urban centers, in areas polluted by industrial waste or agricultural areas where use is made of pesticides, the sperm are less mobile than the 20% of people living in small towns.
To promote greater information in the field of andrology and spread a culture of prevention, the Italian Society of Andrology, always committed to the dissemination and prevention, in addition to the Andrology Prevention Week, the initiative came in 2011, 11th edition, distributed free in all pharmacies from November, the Italian magazine "I Man", the first magazine devoted to information, education and prevention Andrology.
In the magazine, in collaboration with leading Italian specialist urologists, the reader will find useful information and always current on the most important issues related to sexual and reproductive health in all ages, from children to the elderly, such as disorders' ejaculation and orgasm, erection problems, sexually transmitted diseases and sexual infections, infertility.
"That's because, unlike drugs that intervene only available on erectile function, clavulanic acid acts on the central nervous system, acting on the action of serotonin and dopamine, molecules that play a key role in all 3 phases of sexual function, arousal, erection and release. This is the first solution capable of acting in this manner - explains Prof.
Furio Pirozzi Farina, President of the Italian Society of Andrology - The mechanism of action of clavulanic acid, in addition to showing positive effects the male with ED of psychogenic origin, opens up new hopes for the treatment of disorders related to arousal problems, such as premature ejaculation, and also in the treatment of female sexual dysfunction. "After the publication [i] in 2009 study preclinical rat produced by the University of Utrecht (Netherlands) from which emerged an increase in sexual activity following the administration of the drug, the trial continued with a human clinical trial Phase IIa double-blind, randomized, placebo-controlled trial that evaluated the safety and preliminary efficacy in 39 males aged between 18 and 65 years with ED.
The improvement of erectile function score was measured by the International Index of Erectile Function (IIEF) at a time 8 weeks, also highlighting improved quality of life. Clavulanic acid has been proven safe and well tolerated without significant adverse events. The Phase IIb study (in progress) is double-blind, randomized, placebo-controlled, of 225 men with ED, aged between 18 and 65. The assessment shall include as endpoints, the Sexual Encounter Profile (SEP), assessment of sexual function questionnaire, the IIEF and the assessment of quality of life.
"Dysfunction dysfunction and sexual performance are the issues on which, thanks to a series of initiatives to raise awareness at national and local, has torn the veil of embarrassment - says Pirozzi Farina - Little is known, for example, infertility and factors risk, and there are many misconceptions and falsehoods that revolve around the male sexual health. Much has been achieved in recent years, but the same must be done to ensure that culture andrological and take care of their sexuality take root among the Italian men.
"For several years debating the risks to health from exposure to electromagnetic waves, especially those emitted by mobile phones, more and more accessible to adults and adolescents, especially in Western countries. One of the themes of particular interest is related to the influence on sperm quality and thus the impairment of reproductive capacity. A study recently conducted by experts from the University of Catania and published in the journal International Journal of Andrology analyzes several research done on animals and humans to observe the effects on reproductive capacity which can be caused by exposure to electromagnetic radiation of mobile phones.
"The scientific community continues to reflect the adverse effects of electromagnetic waves, especially in light of the increasingly widespread use of mobile phones in Western populations and the simultaneous reduction fertility - says Pirozzi Farina - In the peninsula, from the 70s to today, men have seen a decrease in the number of spermatozoa in a milliliter of semen has gone from 71 million to 60 million. And if thirty years ago a sperm of two was mobile, now it is only 30%. So there is a fertility problem, but it is important to clarify what can be considered truly dangerous items and substances for general health and sexual, so as not to create unnecessary alarm.
"The damage caused by radiation from mobile phones through hyperthermia and oxidative stress, are located mainly in the Leydig cells, and sperm in the tubules seminifere. The exposure reduces testosterone biosynthesis in particular, impairs spermatogenesis and sperm DNA damage. "The first recommendation to do is to avoid holding the phone in the pocket of his pants - adds Pirozzi Farina - The same precaution should be taken with other equipment, for example, when using the laptop resting on my legs. Equally important is to contain the 'use. Some studies in fact show that the degree of damage of the sperm is directly linked to the time of exposure to electromagnetic radiation. Both of these bad habits can lead to hyperthermia and oxidative stress.
"The consequences are found in both the mobility in the morphology of spermatozoa. The increase of oxidative stress also affects the lipid membrane and the DNA of sperm. "These are changes that appear to be directly related to prolonged use of the phone. To date, however, no studies of well depth decree the negative interference on the reproductive function.
There is, however, evidence of other risk factors for reproduction, such as environmental pollution. Lead, carbon monoxide and fine dust accumulate in the testicles with effects on sperm. The Studies prove who is very exposed, such as policemen or toll collectors "- concludes Pirozzi Farina. Several studies also show that in men living in large urban centers, in areas polluted by industrial waste or agricultural areas where use is made of pesticides, the sperm are less mobile than the 20% of people living in small towns.
To promote greater information in the field of andrology and spread a culture of prevention, the Italian Society of Andrology, always committed to the dissemination and prevention, in addition to the Andrology Prevention Week, the initiative came in 2011, 11th edition, distributed free in all pharmacies from November, the Italian magazine "I Man", the first magazine devoted to information, education and prevention Andrology.
In the magazine, in collaboration with leading Italian specialist urologists, the reader will find useful information and always current on the most important issues related to sexual and reproductive health in all ages, from children to the elderly, such as disorders' ejaculation and orgasm, erection problems, sexually transmitted diseases and sexual infections, infertility.